Scientists Using Oxygen Therapy to Reverse Human Ageing

Turning Back the Clock – Scientists Reverse Aging with Oxygen Therapy

Written by
29 December 2020
Category: Wellness
Views: 370

The topic of aging and the methods to counter it has generated great interest and, in turn, volumes of research. For decades, scientists and cosmetologists have been trying to find a way to either pause or reverse the wear and tear of aging on humans. While they have had some success in the area, there hasn’t been a huge development until now!

By using Hyperbaric Oxygen Therapy (HBOT) with a new protocol called intermittent hyperoxia, scientists have been able to achieve two major feats that have had a significant impact on reversing aging:

1. Increasing the length of the telomeres.

2. Reducing the number of senescent cells in the body.

What Are Telomeres and Senescent Cells?

Unless you are a professional in medicine or biochemistry, coming across these terms is highly unlikely. So, let’s become familiar with them and understand their meaning.

Telomere

BOOST02 TELOMERE

At the end of every strand of our DNA are protective caps called telomeres, and these are similar to the plastic ends on your shoelaces. The telomeres help to protect our DNA from damage during the copying process.

Like an hourglass losing sand, the DNA loses a small amount of the telomere every time it’s copied, making it shorter and shorter. Eventually, it gets so short that there is not enough telomere remaining to allow another copy without damaging the DNA. It is widely accepted that your DNA can replicate 60 to 70 times until a telomere is too short to allow further replication and the cell becomes senescent.

Senescent Cell

These cells are a core driver of the pathological hallmarks of aging including chronic inflammation, cancer, and impaired stem cell renewal. Senescent cells stop dividing and enter a state of permanent growth arrest without dying. They continue to be metabolically active, sending out inflammatory signals that attract immune cells to destroy them. The problem is that some senescent cells evade destruction and hang around in a zombie-like state, polluting surrounding tissue with inflammatory mediators and other disruptive signals that, when present over the long term, will significantly degrade tissue structure and function, disrupt regeneration, and produce chronic inflammation. Senescent cells accumulate as we age, accelerating the development and progression of nearly all common age-related diseases.

Anti-Aging Research

The impact of aging on telomeres, cell senescence, and their subsequent contribution to age-related diseases has been subject to much research and debate in the scientific community. Dr. Shai Efrati, a scientist whose research has recently demonstrated that HBOT can induce cognitive enhancements in healthy aging adults via improved cerebral blood flow, has more recently focused on other anti-aging benefits of oxygen therapy and discovered the impact of intermittent hyperoxia on the length of telomeres and cell senescence.

The Hyperoxic-Hypoxic Paradox

Tissue oxygenating HBOT has been around since the 1600’s but recent breakthroughs in effectiveness by Dr. Efrati and his team are causing researchers to take a deeper look at what he calls the Hyperoxic-Hypoxic Paradox. While traditional HBOT only focused on the delivery of oxygen, this new study shows that exposure to fluctuating oxygen levels during hyperbaric treatment may be just as important. 

Hypoxia is one of the most powerful inducers of gene expression, metabolic changes, and regenerative processes, including stem cell proliferation. Dr. Efrati’s research has shown that intermittent hyperoxia, or repeated intervals of high oxygen exposure followed by lower oxygen exposure, can induce many of the same mediators and cellular mechanisms which typically occur during hypoxia. This is called the Hyperoxic-Hypoxic Paradox.

Efrati’s Breakthrough Study

Efrati’s 90-day study involved exposing 35 healthy individuals aged 64 and over to a protocol of 60 sessions of 100% oxygen at 2 ATA, including three air breaks during each session to utilize the hyperoxic-hypoxic paradox and minimize the risk of oxygen toxicity. Each participant provided blood samples before, during, and at the end of the treatments and sometime after the series of treatments concluded. The researchers then analyzed various immune cells in the blood and compared the results.

The findings indicated that the treatments actually reversed the aging process in two of its major aspects: the telomeres at the ends of the chromosomes grew longer instead of shorter at a rate of 20%-38% for the different cell types, and the percentage of senescent cells in the overall cell population was reduced significantly by 11% to 37% depending on cell type.

The results show a clear increase in telomere length during the course of the study.

The researchers themselves are optimistic about the findings. “Until now, interventions, such as lifestyle modifications and intense exercise, were shown to have some inhibiting effect on telomere shortening,” said Dr. Hadanny. “But in our study, only three months of HBOT were able to elongate telomeres at rates far beyond any currently available interventions or lifestyle modifications. With this pioneering study, we have opened a door for further research on the cellular impact of HBOT and its potential for reversing the aging process.”

The LiveO2 Advantage

Efrati’s body of work in HBOT research clearly shows a correlation between increased cellular oxygenation and anti-aging effects and has demonstrated the regenerative effect of the hyperoxic-hypoxic paradox. The only problem with HBOT therapy is it is expensive, not covered by most insurance, and very time consuming. The LiveO2 Adaptive Contrast system follows a similar protocol, but speeds up and enhances the process using exercise to increase blood flow and respiration during training sessions, while bringing the session times down to 15-minutes. Best of all the cost is dramatically reduced with LiveO2 compared to traditional Hyperbarics. 

Conclusion

Although it has taken years of research, science has finally been able to find a treatment that is an unprecedented leap forward towards the reversal of human aging. While there is still much work to do, this development is a true breakthrough and has presented researchers all over the world with a clear direction to head in and focus on.

While the research goes on, oxygen therapies, specifically those that employ the hyperoxic-hypoxic paradox, present an innovative, leading-edge method to fight aging and enhance cognitive and physiological functions now.

 

Hachmo Y, Hadanny A, Abu Hamed R, Daniel-Kotovsky M, Catalogna M, Fishlev G, Lang E, Polak N, Doenyas K, Friedman M, Zemel Y, Bechor Y, Efrati S. Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial. Aging (Albany NY). 2020; 12:22445-22456. https://doi.org/10.18632/aging.202188

Hadanny A, Daniel-Kotovsky M, Suzin G, Boussi-Gross R, Catalogna M, Dagan K, Hachmo Y, Abu Hamed R, Sasson E, Fishlev G, Lang E, Polak N, Doenyas K, et al. Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial. Aging (Albany NY). 2020; 12:13740–61. https://doi.org/10.18632/aging.103571

Hadanny A, Efrati S. The hyperoxic-hypoxic paradox. Biomolecules. 2020; 10:958. https://doi.org/10.3390/biom10060958

 


ARE YOU READY TO
FEEL OPTIMIZED?


For a limited time, get over 60% off your first two training sessions! The offer includes a fitness assessment, two private training sessions with an expert coach and O2 assisted breathwork.

Ready to take the next step? Then don’t delay: Talk to a Boost O2 specialist today, by phone or message—for a FREE 30-minutes, 1-on-1 consultation, on how Boost O2 can help improve your overall health, fitness and well-being.

+6288290020309


CONTACT US

For more information on owning your own LiveO2 system at home or partnering with Boost O2 at new location, contact rob@liveo2.com to book a call, and speak direct with a Live O2 senior representative

©️2020 PT Oxygen Two Indonesia, also known as Boost O2 does not provide medical advice and the programs offered and the equipment used do not have nor require FDA approval in the USA. The equipment used is not a medical device and is not intended to diagnose, treat, cure, or prevent any disease. You may want to consult a doctor before making any change in exercise or oxygen consumption. Exercise with oxygen training has not been tested or conclusively proven to help prevent or cure any type of condition. Should you believe the information provided by Boost O2 states otherwise, please inform us directly at clarification@boostmyo2.com, so that we may amend our materials accordingly. If you have further concerns, please read and/or download the FDA’s “General Wellness: Policy for Low Risk Devices” before adopting an Exercise with Oxygen Training program.

Free shipping is offered on orders with a minimum subtotal of $150 less discounts. Free shipping is only available in the contiguous U.S. and excludes Fitness and Digital items.
For media inquiries please contact us at media@onnit.com.
In thanks to military and first responders, we're extending a 15% discount off MSRP for all products purchased at Onnit.com.
To qualify, simply verify your status during checkout on the payment step. We verify through ID.me, our trusted technology partner for secure digital identity verification.
After verification, your discount will auto-apply on that order and all future orders.
Please note that this discount cannot be combined with coupons.
If you have any questions or issues with the verification process, please don't hesitate to reach out to Customer Service.
* US Military members, please choose United States as your destination country, as this will ensure your package ships via USPS and that you are not given international shipping rates.
With a subscription, you'll get your favorite Onnit products whenever you want at 15% off MSRP. All automatic, worry free, and with our same great money back guarantee.
Cancel or adjust your order at any time, hassle free. Your payment method will only be charged right before your order ships. The discount applied every time is 15% off MSRP or the current sale discount, whichever is greater. For more information, see the complete Onnit Subscription Terms & Conditions and Frequently Asked Questions.

Secure Shopping

We implement a variety of security measures to maintain the safety of your personal information when you place an order or enter, submit, or access any information on our website. We incorporate physical, electronic, and administrative procedures to safeguard the confidentiality of your personal information, including Secure Sockets Layer (SSL) for the encryption of all financial transactions through the website. We use industry-standard, 256bit SSL encryption to protect your personal information online, and we also take several steps to protect your personal information in our facilities. For example, when you visit the website, you access servers that are kept in a secure physical environment, behind a locked cage and a hardware firewall. After a transaction, your credit card information is not stored on our servers.